Ccl2^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Ccl2^tm1Lex
• Name: C-C motif chemokine ligand 2; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5462245
• Synonyms: MCP-1^-
• Gene: Ccl2 Location: Chr11:81926403-81928278 bp, + strand Genetic Position: Chr11, 49.82 cM, cytoband C-E1
• Alliance: Ccl2^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191510
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A selection cassette replaced most of exon 2 (information provided by Taconic, see IMSR links).

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Ccl2^tm1Lex/Ccl2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
cellular	N
impaired macrophage chemotaxis	N
hematopoietic system	N
impaired macrophage chemotaxis	N
immune system	N
impaired macrophage chemotaxis	N

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccl2 Mutation: 25 strains or lines available

References

• Original: J:191510 Oh DY, et al., Increased macrophage migration into adipose tissue in obese mice. Diabetes. 2012 Feb;61(2):346-54
• All: 1 reference(s)