Rr21^tm1Jta
Targeted Allele Detail

Summary

• Symbol: Rr21^tm1Jta
• Name: regulatory region 21; targeted mutation 1, Jussi Taipale
• MGI ID: MGI:5463412
• Synonyms: Myc-335 cKO
• Gene: Rr21 Location: Chr15:61490136-61491875 bp Genetic Position: Chr15, Syntenic
• Alliance: Rr21^tm1Jta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191217
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A 1740 bp region that lies 335 kb upstream of the transcription start site of Myc (Chr15:61449842-61451581 (NCBI37/mm9)) was flanked with loxP sites and an FRT site flanked neomycin resistance gene cassette was inserted upstream of the 3' loxP site. (J:191217)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr21 Mutation: 0 strains or lines available

References

• Original: J:191217 Sur IK, et al., Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors. Science. 2012 Dec 7;338(6112):1360-3
• All: 1 reference(s)