b2b1456Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b1456Clo
• Name: Mutant line 1456; Bench to Bassinet Program (B2B/CVDC), mutation 1456 Cecilia Lo
• MGI ID: MGI:5463441
• Synonyms: Shiner
• Gene: b2b1456Clo Location: unknown
• Alliance: b2b1456Clo page

Mutant 1456-002-LA has dextrocardia and dextrogastria with inverted liver lobation.

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, b2b1456Clo, and may be present in stocks carrying this mutation.

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b1456Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis:
Cardiac phenotype: Dextrocardia and atrioventricular septal defect associated with heterotaxy.
Noncardiac phenotype: Left pulmonary isomerism, situs inversus

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0100	Situs inversus totalis
0110	Dextrocardia
0190	Heterotaxy syndrome
1100	Atrioventricular canal (endocardial cushion defect)
4239	Left bronchial isomerism

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)