b2b1801.2Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b1801.2Clo
• Name: Mutant line 1801.2; Bench to Bassinet Program (B2B/CVDC), mutation 1801, subline 2 Cecilia Lo
• MGI ID: MGI:5463581
• Gene: b2b1801.2Clo Location: unknown
• Alliance: b2b1801.2Clo page

Mutant 1801-004-LC shows a slightly stenotic transverse arch and the pulmonary artery is positioned further posterior which confirms the micro-CT finding of double outlet right ventricle (DORV)

Show the 7 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• Mutation details: This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. It is a subline of b2b1801Clo.

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b1801.2Clo Mutation: 1 strain or line available

Notes

This mutation was derived from the parent line b2b1801Clo.

Summative Diagnosis:
Mutant Type 2:
Cardiovascular phenotype: Double outlet right ventricle (DORV)/overriding aorta (Ao), hypoplastic aortic arch, subaortic ventricular septal defect (VSD), and muscular ventricular septal defect (mVSD)

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0600	Double outlet right ventricle
1200	Coarctation
1300	Ventricular septal defect
1320	Ventricular septal defect, muscular
1432	Overriding aortic valve

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)