Vps52^tm1.2Kab
Targeted Allele Detail

Summary

• Symbol: Vps52^tm1.2Kab
• Name: VPS52 GARP complex subunit; targeted mutation 1.2, Kuniya Abe
• MGI ID: MGI:5463590
• Gene: Vps52 Location: Chr17:34174786-34186009 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Vps52^tm1.2Kab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190873
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked pgk-neo cassette were inserted in intron 1 and a loxP site was inserted in intron 2 via homologous recombination. Recombinase mediated recombination removed the pgk-neo cassette and exon 2. (J:190873)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vps52 Mutation: 42 strains or lines available

References

• Original: J:190873 Sugimoto M, et al., Molecular identification of t(w5): Vps52 promotes pluripotential cell differentiation through cell-cell interactions. Cell Rep. 2012 Nov 29;2(5):1363-74
• All: 1 reference(s)