Nubp1^m1Nisw
Chemically induced Allele Detail

Summary

• Symbol: Nubp1^m1Nisw
• Name: nucleotide binding protein 1; mutation 1, Lee Niswander
• MGI ID: MGI:5463617
• Synonyms: line3-2
• Gene: Nubp1 Location: Chr16:10229812-10242292 bp, + strand Genetic Position: Chr16, 5.61 cM
• Alliance: Nubp1^m1Nisw page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: ENU induced two C to A transversions at position 743 and 803 resulting in a Threonine to Lysine and Proline to Glutamine amino acid change, respectively. Protein expression is detected in the distal lung epithelium; however the interaction with Nubp2 is disrupted in vitro. (J:191793)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nubp1 Mutation: 17 strains or lines available

References

• Original: J:191793 Schnatwinkel C, et al., Nubp1 is required for lung branching morphogenesis and distal progenitor cell survival in mice. PLoS One. 2012;7(9):e44871
• All: 1 reference(s)