Arih2^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Arih2^tm1Mak
• Name: ariadne RBR E3 ubiquitin protein ligase 2; targeted mutation 1, Tak Mak
• MGI ID: MGI:5463664
• Gene: Arih2 Location: Chr9:108480141-108526585 bp, - strand Genetic Position: Chr9, 59.54 cM
• Alliance: Arih2^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191066
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment including exons 6 - 8 was replaced with a pgk-neo cassette in inverse orientation via homologous recombination. (J:191066)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arih2 Mutation: 64 strains or lines available

References

• Original: J:191066 Lin AE, et al., ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system. Nat Immunol. 2013 Jan;14(1):27-33
• All: 1 reference(s)