Vtcn1tm1Xxz
Targeted Allele Detail
|
Symbol: |
Vtcn1tm1Xxz |
Name: |
V-set domain containing T cell activation inhibitor 1; targeted mutation 1, Xingxing Zang |
MGI ID: |
MGI:5463743 |
Synonyms: |
B7x- |
Gene: |
Vtcn1 Location: Chr3:100732775-100804238 bp, + strand Genetic Position: Chr3, 43.78 cM
|
Alliance: |
Vtcn1tm1Xxz page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:177612
|
Parent Cell Line: |
J1 (ES Cell)
|
Strain of Origin: |
129S4/SvJae
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: A 2.5 kb fragment of exon 3 and part of intron 3 and a 5.2 kb containing exon 5, intron 5 and exon 6 were cloned into XhoI and salI sites of target vector pKO (Lexicon). PGK promoter-derived Neomycin phosphotransferase cDNA (positive selection) and Diphtheria toxin A china cDNA (negative selection) were cloned into AscI and RsrII sites of the vector.
(J:177612)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Vtcn1 Mutation: |
24 strains or lines available
|
|
Original: |
J:177612 Wei J, et al., Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity. J Exp Med. 2011 Aug 1;208(8):1683-94 |
All: |
5 reference(s) |
|