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Vtcn1tm1Xxz
Targeted Allele Detail
Summary
Symbol: Vtcn1tm1Xxz
Name: V-set domain containing T cell activation inhibitor 1; targeted mutation 1, Xingxing Zang
MGI ID: MGI:5463743
Synonyms: B7x-
Gene: Vtcn1  Location: Chr3:100732775-100804238 bp, + strand  Genetic Position: Chr3, 43.78 cM
Alliance: Vtcn1tm1Xxz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177612
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2.5 kb fragment of exon 3 and part of intron 3 and a 5.2 kb containing exon 5, intron 5 and exon 6 were cloned into XhoI and salI sites of target vector pKO (Lexicon). PGK promoter-derived Neomycin phosphotransferase cDNA (positive selection) and Diphtheria toxin A china cDNA (negative selection) were cloned into AscI and RsrII sites of the vector. (J:177612)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vtcn1 Mutation:  24 strains or lines available
References
Original:  J:177612 Wei J, et al., Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity. J Exp Med. 2011 Aug 1;208(8):1683-94
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory