Atm^tm1Shzh
Targeted Allele Detail

Summary

• Symbol: Atm^tm1Shzh
• Name: ataxia telangiectasia mutated; targeted mutation 1, Shan Zha
• MGI ID: MGI:5463796
• Synonyms: ATM^KDN
• Gene: Atm Location: Chr9:53350449-53448040 bp, - strand Genetic Position: Chr9, 29.12 cM, cytoband C-D
• Alliance: Atm^tm1Shzh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191288
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Nucleotide substitutions Mutation details: Exon 3 was replaced with a floxed neo cassette and a modified exon 3 in which an A to C and T to A transversion results in the amino acid substitutions of aspartic acid for alanine at position 2870 (A2870D) and lysine for asparagine at position 2875 (N2875K). These mutations result in a kinase dead protein. (J:191288)

Generation of the Atm^tm1Shzh and Atm^tm1.1Shzh alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atm Mutation: 170 strains or lines available

References

• Original: J:191288 Yamamoto K, et al., Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice. J Cell Biol. 2012 Aug 6;198(3):305-13
• All: 1 reference(s)