Cnn1^tm1.1Jomm
Targeted Allele Detail

Summary

• Symbol: Cnn1^tm1.1Jomm
• Name: calponin 1; targeted mutation 1.1, Joseph M Miano
• MGI ID: MGI:5463909
• Gene: Cnn1 Location: Chr9:22010501-22020517 bp, + strand Genetic Position: Chr9, 8.3 cM, cytoband A2-A4
• Alliance: Cnn1^tm1.1Jomm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191843
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ and floxed neo cassette replaced exon 1, intron 1 (containing 4 CArG elements), and exon 2. Cre-mediated recombination removed the neo cassette. No beta-galatosidase activity is detected in heterozygous mice. (J:191843)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnn1 Mutation: 17 strains or lines available

References

• Original: J:191843 Long X, et al., Smooth muscle calponin: an unconventional CArG-dependent gene that antagonizes neointimal formation. Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2172-80
• All: 1 reference(s)