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Uimc1tm1.2Amj
Targeted Allele Detail
Summary
Symbol: Uimc1tm1.2Amj
Name: ubiquitin interaction motif containing 1; targeted mutation 1.2, Anton M Jetten
MGI ID: MGI:5463917
Synonyms: RAP80-
Gene: Uimc1  Location: Chr13:55175693-55248113 bp, - strand  Genetic Position: Chr13, 29.8 cM, cytoband B2
Alliance: Uimc1tm1.2Amj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:191827
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 4 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 6 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 4 - 6. (J:191827)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Uimc1tm1.2Amj
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Uimc1 Mutation:  34 strains or lines available
References
Original:  J:191827 Yin Z, et al., RAP80 is critical in maintaining genomic stability and suppressing tumor development. Cancer Res. 2012 Oct 1;72(19):5080-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory