Uimc1tm1.2Amj
Targeted Allele Detail
|
Symbol: |
Uimc1tm1.2Amj |
Name: |
ubiquitin interaction motif containing 1; targeted mutation 1.2, Anton M Jetten |
MGI ID: |
MGI:5463917 |
Synonyms: |
RAP80- |
Gene: |
Uimc1 Location: Chr13:55175693-55248113 bp, - strand Genetic Position: Chr13, 29.8 cM, cytoband B2
|
Alliance: |
Uimc1tm1.2Amj page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:191827
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
C57BL/6
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: A loxP site was inserted upstream of exon 4 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 6 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 4 - 6.
(J:191827)
|
|
|
Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
|
Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
---|
Loading... | | | involves: BALB/cJ * C57BL/6 | | | | involves: 129S2/SvPas * BALB/cJ * C57BL/6 | | | | involves: 129S2/SvPas * BALB/cJ * C57BL/6 | |
|
Phenotypes: |
Affected Systems |
|
|
|
|
cellular
|
√
|
|
|
abnormal cell cycle checkpoint function
|
√
|
|
|
decreased fibroblast proliferation
|
√
|
|
|
early cellular replicative senescence
|
√
|
|
|
endocrine/exocrine glands
|
√
|
|
|
increased T cell derived lymphoma incidence
|
√
|
|
|
hematopoietic system
|
√
|
|
|
increased T cell derived lymphoma incidence
|
√
|
|
|
homeostasis/metabolism
|
√
|
|
|
increased susceptibility to xenobiotic induced morbidity/mortality
|
√
|
|
|
increased incidence of tumors by chemical induction
|
√
|
|
|
immune system
|
√
|
|
|
increased T cell derived lymphoma incidence
|
√
|
|
|
mortality/aging
|
√
|
√
|
|
increased susceptibility to xenobiotic induced morbidity/mortality
|
√
|
|
|
decreased tumor-free survival time
|
|
√
|
|
neoplasm
|
√
|
|
√
|
increased incidence of tumors by chemical induction
|
√
|
|
|
increased tumor growth/size
|
|
|
√
|
increased lymphoma incidence
|
√
|
|
√
|
increased T cell derived lymphoma incidence
|
√
|
|
|
increased B cell derived lymphoma incidence
|
√
|
|
|
increased incidence of tumors by ionizing radiation induction
|
√
|
|
√
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Uimc1 Mutation: |
34 strains or lines available
|
|
Original: |
J:191827 Yin Z, et al., RAP80 is critical in maintaining genomic stability and suppressing tumor development. Cancer Res. 2012 Oct 1;72(19):5080-90 |
All: |
1 reference(s) |
|