Hdac10^{tm1.1(KOMP)Mbp}
Targeted Allele Detail

Summary

• Symbol: Hdac10^{tm1.1(KOMP)Mbp}
• Name: histone deacetylase 10; targeted mutation 1.1, Mouse Biology Program, UC Davis
• MGI ID: MGI:5463976
• Gene: Hdac10 Location: Chr15:89007510-89012903 bp, - strand Genetic Position: Chr15, 44.64 cM
• Alliance: Hdac10^{tm1.1(KOMP)Mbp} page
• IMPC: Hdac10 gene page

Mutation origin

• Mutant Cell Line: DEPD00557_2_E01
• Germline Transmission: Earliest citation of germline transmission: J:188991
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 4733 starting at position 89007510 and ending at position 89012243 of Chromosome 15 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Subsequent cre expression excised this neomycin resistance cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:157064, J:188991)

Expression

In Mice Carrying this Mutation:	55 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hdac10 Mutation: 38 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 7 reference(s)