Rr123^tm1.1Vbo
Targeted Allele Detail

Summary

• Symbol: Rr123^tm1.1Vbo
• Name: regulatory region 123; targeted mutation 1.1, Harald von Boehmer
• MGI ID: MGI:5463979
• Synonyms: foxp3^CNS1mut, Foxp3^tm1.1Vbo
• Gene: Rr123 Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: Rr123^tm1.1Vbo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191815
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

Allele Type: Targeted (Modified regulatory region) Mutations: Insertion, Intragenic deletion Rr123^tm1.1Vbo involves 1 genes/genome features (Foxp3) View all Mutation details: The Smad3-binding site (CAGACtGTCTG) in enhancer CNS1 in an intron of Foxp3 was deleted. The loxP site flanked neomycin resistance gene cassette that was inserted downstream was removed through subsequent cre-mediated recombination. (J:191815)

Generation of the Rr123^tm1.1Vbo allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr123 Mutation: 0 strains or lines available

References

• Original: J:191815 Schlenner SM, et al., Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut. J Exp Med. 2012 Aug 27;209(9):1529-35
• All: 2 reference(s)