Cyp11a1^tm1.1Bcc
Targeted Allele Detail

Summary

• Symbol: Cyp11a1^tm1.1Bcc
• Name: cytochrome P450, family 11, subfamily a, polypeptide 1; targeted mutation 1.1, Bon-Chu Chung
• MGI ID: MGI:5464022
• Synonyms: Cyp11a1^E1-loxP
• Gene: Cyp11a1 Location: Chr9:57913694-57934306 bp, + strand Genetic Position: Chr9, 31.63 cM
• Alliance: Cyp11a1^tm1.1Bcc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191801
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced part of exon 1. Cre-mediated recombination removed the neo cassette. Western blot analysis confirmed the absence of protein expression in E18.5 adreanal tissue. (J:191801)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp11a1 Mutation: 42 strains or lines available

References

• Original: J:191801 Huang CC, et al., Fetal glucocorticoid synthesis is required for development of fetal adrenal medulla and hypothalamus feedback suppression. Endocrinology. 2012 Oct;153(10):4749-56
• All: 2 reference(s)