Tab2^tm2.1Aki
Targeted Allele Detail

Summary

• Symbol: Tab2^tm2.1Aki
• Name: TGF-beta activated kinase 1/MAP3K7 binding protein 2; targeted mutation 2.1, Shizuo Akira
• MGI ID: MGI:5464099
• Synonyms: TAB2^flox
• Gene: Tab2 Location: Chr10:7781417-7831994 bp, - strand Genetic Position: Chr10, 2.56 cM
• Alliance: Tab2^tm2.1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81816
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Flanking loxP sites were introduced to the large exon and a floxed neo cassette was inserted into the upstream intron. Cre-mediated recombination removed the neo cassette and left the exon floxed. (J:81816)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tab2 Mutation: 31 strains or lines available

References

• Original: J:81816 Sanjo H, et al., TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling. Mol Cell Biol. 2003 Feb;23(4):1231-8
• All: 7 reference(s)