Arhgef15^tm1Nmoc
Targeted Allele Detail

Summary

• Symbol: Arhgef15^tm1Nmoc
• Name: Rho guanine nucleotide exchange factor 15; targeted mutation 1, Naoki Mochizuki
• MGI ID: MGI:5464934
• Synonyms: Arhgef15^lacZ
• Gene: Arhgef15 Location: Chr11:68833981-68848306 bp, - strand Genetic Position: Chr11, 42.21 cM
• Alliance: Arhgef15^tm1Nmoc page

Retardation of retinal vascular growth in Arhgef15^tm1Nmoc/Arhgef15^tm1Nmoc mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191977
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: The first two coding exons were replaced with a lox71 site, lacZ, polyadenylation sequence, neo cassette, lox2272 site, polyadenylation sequence and FRT site. Immunohistochemistry confirmed the absence of protein expression in non-endothelial cells in retinal blood vessels. (J:191977)

Generation of the Arhgef15^tm1Nmoc allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgef15 Mutation: 48 strains or lines available

References

• Original: J:191977 Kusuhara S, et al., Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells. PLoS One. 2012;7(9):e45858
• All: 1 reference(s)