Foxn1^nu-2J
Spontaneous Allele Detail

Summary

• Symbol: Foxn1^nu-2J
• Name: forkhead box N1; nude 2 Jackson
• MGI ID: MGI:5464997
• Gene: Foxn1 Location: Chr11:78248403-78277384 bp, - strand Genetic Position: Chr11, 46.74 cM
• Alliance: Foxn1^nu-2J page

Mutation origin

• Strain of Origin: B6.SJL-Ptprc^a Pepc^b/BoyJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: This spontaneous mutation, which fails to complement the original nude mutation, has a 7 nucleotide deletion encompassing chromosome 11 nucleotides 78,371,200-206 (GRCm38). This causes a frameshift that leads to the introduction of 186 novel amino acids beginning at residue 114 and then an early termination codon within the forkhead DNA binding domain. (J:192383, J:222308)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxn1 Mutation: 106 strains or lines available

References

• Original: J:192383 Harris BS, et al., Nude 2 Jackson: A new spontaneous mutation in Foxn1. MGI Direct Data Submission. 2013
• All: 4 reference(s)