Mefv^tm1Bhk
Targeted Allele Detail

Summary

• Symbol: Mefv^tm1Bhk
• Name: Mediterranean fever; targeted mutation 1, Beverly H Koller
• MGI ID: MGI:5465109
• Gene: Mefv Location: Chr16:3525082-3535961 bp, - strand Genetic Position: Chr16, 2.18 cM
• Alliance: Mefv^tm1Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192443
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A targeting vector was designed to replace entire coding region with a neomycin resistance (neo) cassette in reverse orientation to the gene. Northern blot analysis confirmed the absence of transcript expression in elicited peritoneal neutrophils. (J:192443)

Generation of the Mefv^tm1Bhk allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mefv Mutation: 46 strains or lines available

References

• Original: J:192443 Hesker PR, et al., Genetic loss of murine pyrin, the Familial Mediterranean Fever protein, increases interleukin-1beta levels. PLoS One. 2012;7(11):e51105
• All: 2 reference(s)