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Trp53tm3.1Holl
Targeted Allele Detail
Summary
Symbol: Trp53tm3.1Holl
Name: transformation related protein 53; targeted mutation 3.1, Monica Hollstein
MGI ID: MGI:5465276
Synonyms: p53hkiS46A
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance: Trp53tm3.1Holl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:191183
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4 through 9 were replaced with corresponding exons from the human gene with a sequence variant that results in the amino acid substitution of serine with alanine at position 46 (p.S46A). Cre-mediated recombination removed the Loxp site flanked neomycin resistance gene cassette inserted into intron 3. (J:191183)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  240 strains or lines available
References
Original:  J:191183 Feng L, et al., Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence. Cell Cycle. 2006 Dec;5(23):2812-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory