Srgap3^tm1.1Zi
Targeted Allele Detail

Summary

• Symbol: Srgap3^tm1.1Zi
• Name: SLIT-ROBO Rho GTPase activating protein 3; targeted mutation 1.1, Dusan Bartsch
• MGI ID: MGI:5465281
• Gene: Srgap3 Location: Chr6:112694932-112924227 bp, - strand Genetic Position: Chr6, 52.54 cM, cytoband E3
• Alliance: Srgap3^tm1.1Zi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192388
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 3 was replaced with a modified one with a premature stop codon. This mutation resembled the breakpoint of the t(3; X)(p25;p11) translocation. Flp-mediated recombination removed the FRT-flanked neo cassette inserted downstream of the modified exon 3. Western blot anlaysis confirmed the absence of protein expression in the adult cortex. (J:192388)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srgap3 Mutation: 62 strains or lines available

References

• Original: J:192388 Waltereit R, et al., Srgap3(-)/(-) mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes. FASEB J. 2012 Nov;26(11):4418-28
• All: 3 reference(s)