Tlr4^tm1.1Djh
Targeted Allele Detail

Summary

• Symbol: Tlr4^tm1.1Djh
• Name: toll-like receptor 4; targeted mutation 1.1, David J Hackam
• MGI ID: MGI:5465308
• Synonyms: TLR4^del
• Gene: Tlr4 Location: Chr4:66745788-66765338 bp, + strand Genetic Position: Chr4, 34.66 cM
• Alliance: Tlr4^tm1.1Djh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192520
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The Flp recombinase (flp deleter), which effectively recombined the Frt sites flanking the neo gene, left behind the loxP sites flanking the exon 2. Cre-recombination removed the floxed portion. (J:192520)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr4 Mutation: 91 strains or lines available

References

• Original: J:192520 Sodhi CP, et al., Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis. Gastroenterology. 2010 Jan;138(1):185-96
• All: 10 reference(s)