Esr1^tm4.2Ksk
Targeted Allele Detail

Summary

• Symbol: Esr1^tm4.2Ksk
• Name: estrogen receptor 1 (alpha); targeted mutation 4.2, Kenneth S Korach
• MGI ID: MGI:5465426
• Synonyms: Ex3alphaERKO, Ex3-ERKO
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^tm4.2Ksk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191182
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed TK-neo selection cassette was inserted downstream of exon 3 and a third loxP site was inserted upstream. The selection cassette and exon 3 were subsequently removed from properly targeted mice by cre excision. (J:191182)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 68 strains or lines available

References

• Original: J:191182 Hewitt SC, et al., Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene. FASEB J. 2010 Dec;24(12):4660-7
• All: 24 reference(s)