Ifitm1^tm1.1Ieg
Targeted Allele Detail

Summary

• Symbol: Ifitm1^tm1.1Ieg
• Name: interferon induced transmembrane protein 1; targeted mutation 1.1, Institute of Experimental Genetics
• MGI ID: MGI:5465441
• Synonyms: Ifitm1^tm1IEG
• Gene: Ifitm1 Location: Chr7:140547342-140549740 bp, + strand Genetic Position: Chr7, 86.2 cM, cytoband F5
• Alliance: Ifitm1^tm1.1Ieg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192287
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: A genomic fragment including exons 2 and 3, encompassing the entire coding region, was replaced with a lacZ cassette and floxed neo cassette via homologous recombination. The lacZ gene was inserted in frame into the first codon of the gene. Cre mediated recombination removed the neo cassette. (J:192287)

Generation of the Ifitm1^tm1.1Ieg allele

Expression

In Mice Carrying this Mutation:	114 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ifitm1 Mutation: 42 strains or lines available

References

• Original: J:192287 Klymiuk I, et al., In vivo functional requirement of the mouse Ifitm1 gene for germ cell development, interferon mediated immune response and somitogenesis. PLoS One. 2012;7(10):e44609
• All: 1 reference(s)