Gatm^tm1.1Isb
Targeted Allele Detail

Summary

• Symbol: Gatm^tm1.1Isb
• Name: glycine amidinotransferase (L-arginine:glycine amidinotransferase); targeted mutation 1.1, Dirk Isbrandt
• MGI ID: MGI:5465452
• Synonyms: AGAT^-
• Gene: Gatm Location: Chr2:122424954-122441758 bp, - strand Genetic Position: Chr2, 60.63 cM
• Alliance: Gatm^tm1.1Isb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191142
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 3 was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. Western blot analysis confirmed the absence of protein expression in the kidney. (J:191142)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gatm Mutation: 22 strains or lines available

References

• Original: J:191142 Choe CU, et al., L-arginine:glycine amidinotransferase deficiency protects from metabolic syndrome. Hum Mol Genet. 2013 Jan 1;22(1):110-23
• All: 12 reference(s)