Tg(APOE-FGF23*R176Q)#Ack
Transgene Detail

Summary

• Symbol: Tg(APOE-FGF23*R176Q)#Ack
• Name: transgene insertion, Andrew C Karaplis
• MGI ID: MGI:5465569
• Synonyms: FGF23-TG
• Transgene: Tg(APOE-FGF23*R176Q)#Ack Location: unknown
• Alliance: Tg(APOE-FGF23*R176Q)#Ack page

Transgene origin

• Strain of Origin: C57BL/6J x CBA

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOE-FGF23*R176Q)#Ack expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FGF23 (8074)

  Fgf23

  (MGI:1891427)

• Mutation details: This transgene consists of the human APOE promoter with exon 1 and part of exon 2 and the human FGF23 cDNA with the R176Q mutation tagged with a myc epitope followed by the APOE poly(A) and hepatic control region. The APOE promoter drives expression of FGF23 in the liver. Two lines were established however, the pound symbol (#) is used because the line is not specified and lines are pooled. (J:93981)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:93981 Bai X, et al., Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders. Endocrinology. 2004 Nov;145(11):5269-79
• All: 4 reference(s)