Selenop^tm3.1Rfb
Targeted Allele Detail

Summary

• Symbol: Selenop^tm3.1Rfb
• Name: selenoprotein P; targeted mutation 3.1, Raymond F Burk
• MGI ID: MGI:5466366
• Synonyms: Sepp1^c
• Gene: Selenop Location: Chr15:3300249-3309992 bp, + strand Genetic Position: Chr15, 1.84 cM
• Alliance: Selenop^tm3.1Rfb page

Curling and splaying of hind limbs in Selenop^tm3.1Rfb/Selenop^tm3.1Rfb Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice fed a selenium-deficient diet

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192636
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked self-excising neo cassette with a 5' loxP site was inserted downstream of exon 5. The neo cassette was either removed by flp-mediated recombination or spontaneously lost, leaving exons 2 through 5 floxed. (J:94077, J:192636)

Generation of the Selenop^tm3.1Rfb allele

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Selenop^tm3.1Rfb/Selenop^tm3.1Rfb Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: C57BL/6 * DBA

Phenotypes:

Affected Systems	cn1
show or hide all annotated terms Sex:
behavior/neurological	√	√
limb grasping	√	√
abnormal gait	√	√
cellular		√
oligozoospermia		√
teratozoospermia		√
growth/size/body	√	√
decreased body weight	√	√
homeostasis/metabolism	√	√
abnormal selenium level	√	√
increased urine selenium level	√	√
renal/urinary system	√	√
increased urine selenium level	√	√
reproductive system		√
oligozoospermia		√
teratozoospermia		√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Selenop Mutation: 24 strains or lines available

References

• Original: J:192636 Hill KE, et al., Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. J Biol Chem. 2012 Nov 23;287(48):40414-24
• All: 4 reference(s)