Cthrc1^tm1Vli
Targeted Allele Detail

Summary

• Symbol: Cthrc1^tm1Vli
• Name: collagen triple helix repeat containing 1; targeted mutation 1, Volkhard Lindner
• MGI ID: MGI:5466394
• Gene: Cthrc1 Location: Chr15:38940327-38950516 bp, + strand Genetic Position: Chr15, 15.35 cM, cytoband C
• Alliance: Cthrc1^tm1Vli page

Fatty liver in Cthrc1^tm1Vli/Cthrc1^tm1Vli mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192096
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neo cassette replaced a portion of intron 1 and exons 2 through 4. Immunohistochemistry confirmed the absence of protein expression in the midbrain. (J:192096)

Generation of the Cthrc1^tm1Vli allele

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cthrc1 Mutation: 34 strains or lines available

References

• Original: J:192096 Stohn JP, et al., Cthrc1, a novel circulating hormone regulating metabolism. PLoS One. 2012;7(10):e47142
• All: 3 reference(s)