Mcat^tm1.1Ssmi
Targeted Allele Detail

Summary

• Symbol: Mcat^tm1.1Ssmi
• Name: malonyl CoA:ACP acyltransferase (mitochondrial); targeted mutation 1.1, Stuart Smith
• MGI ID: MGI:5466512
• Gene: Mcat Location: Chr15:83430998-83439936 bp, - strand Genetic Position: Chr15, 39.4 cM
• Alliance: Mcat^tm1.1Ssmi page

Hair loss and dry skin in tamoxifen treated Mcat^tm1.1Ssmi/Mcat^tm1.1Ssmi Tg(CAG-cre/Esr1*)5Amc/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192213
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Exon 2 was floxed. Flp-mediated recombination removed the FRT-flanked beta-geo selection cassette. (J:192213)

Schematic of the Mcat^tm1.1Ssmi allele

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcat Mutation: 13 strains or lines available

References

• Original: J:192213 Smith S, et al., Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. PLoS One. 2012;7(10):e47196
• All: 2 reference(s)