Mbd5^tm1.1Gxu
Targeted Allele Detail

Summary

• Symbol: Mbd5^tm1.1Gxu
• Name: methyl-CpG binding domain protein 5; targeted mutation 1.1, Guo-Liang Xu
• MGI ID: MGI:5466579
• Synonyms: Mbd5^f
• Gene: Mbd5 Location: Chr2:48839511-49209702 bp, + strand Genetic Position: Chr2, 28.43 cM, cytoband C1
• Alliance: Mbd5^tm1.1Gxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192212
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed. (J:192212)

Generation of the Mbd5^tm1.1Gxu and Mbd5^tm1.2Gxu alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mbd5 Mutation: 68 strains or lines available

References

• Original: J:192212 Du Y, et al., The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice. PLoS One. 2012;7(10):e47358
• All: 1 reference(s)