Mbd5^tm1.2Gxu
Targeted Allele Detail

Summary

• Symbol: Mbd5^tm1.2Gxu
• Name: methyl-CpG binding domain protein 5; targeted mutation 1.2, Guo-Liang Xu
• MGI ID: MGI:5466580
• Gene: Mbd5 Location: Chr2:48839511-49209702 bp, + strand Genetic Position: Chr2, 28.43 cM, cytoband C1
• Alliance: Mbd5^tm1.2Gxu page

Small body size of Mbd5^tm1.2Gxu/Mbd5^tm1.2Gxu mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192212
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination removed exon 1 and the neo cassette. RT-PCR confirmed the absence of protein expression in the brain, pancreas and liver. (J:192212)

Generation of the Mbd5^tm1.1Gxu and Mbd5^tm1.2Gxu alleles

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mbd5 Mutation: 68 strains or lines available

References

• Original: J:192212 Du Y, et al., The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice. PLoS One. 2012;7(10):e47358
• All: 2 reference(s)