Sp7^tm1.1Rnis
Targeted Allele Detail

Summary

• Symbol: Sp7^tm1.1Rnis
• Name: Sp7 transcription factor 7; targeted mutation 1.1, Riko Nishimura
• MGI ID: MGI:5466596
• Synonyms: Osterix-deltaflox
• Gene: Sp7 Location: Chr15:102265038-102275498 bp, - strand Genetic Position: Chr15, 57.51 cM
• Alliance: Sp7^tm1.1Rnis page

Arrest of endochondral ossification and lack of calcification in Sp7^tm1.1Rnis/Sp7^tm1.1Rnis mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191589
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed part of the coding sequence. Immunohistochemistry confirmed the absence of protein expression in the tibia. (J:191589)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sp7 Mutation: 21 strains or lines available

References

• Original: J:191589 Nishimura R, et al., Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification. J Biol Chem. 2012 Sep 28;287(40):33179-90
• All: 2 reference(s)