Bmyc^tm1Mpo
Targeted Allele Detail

Summary

• Symbol: Bmyc^tm1Mpo
• Name: brain expressed myelocytomatosis oncogene; targeted mutation 1, Matti Poutanen
• MGI ID: MGI:5466677
• Gene: Bmyc Location: Chr2:25596891-25597733 bp, + strand Genetic Position: Chr2, 17.82 cM
• Alliance: Bmyc^tm1Mpo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191587
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced a portion of exon 1. RT-PCR confirmed the absence of protein expression in the epididymis. (J:191587)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmyc Mutation: 4 strains or lines available

References

• Original: J:191587 Turunen HT, et al., Loss of Bmyc results in increased apoptosis associated with upregulation of Myc expression in juvenile murine testis. Reproduction. 2012 Oct;144(4):495-503
• All: 1 reference(s)