Trim50^tm1Hta
Targeted Allele Detail

Summary

• Symbol: Trim50^tm1Hta
• Name: tripartite motif-containing 50; targeted mutation 1, Hiroshi Takeshima
• MGI ID: MGI:5466680
• Gene: Trim50 Location: Chr5:135382149-135396859 bp, + strand Genetic Position: Chr5, 75.15 cM
• Alliance: Trim50^tm1Hta page

Abnormal ultrastructural features in Trim50^tm1Hta parietal cells

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191586
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neo cassette replaced part of intron 1 and exon 2. Western blot analysis confirmed the absence of protein expression in the stomach. (J:191586)

Generation of the Trim50^tm1Hta allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim50 Mutation: 23 strains or lines available

References

• Original: J:191586 Nishi M, et al., TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells. J Biol Chem. 2012 Sep 28;287(40):33523-32
• All: 1 reference(s)