Dp(1)21H
Radiation induced Allele Detail

Summary

• Symbol: Dp(1)21H
• Name: duplication, Chr 1, Harwell 21
• MGI ID: MGI:5466681
• Gene: Dp(1)21H Location: unknown Genetic Position: Chr1, Syntenic

Mutation origin

• Strain of Origin: (C3H/HeH x 101/H)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Duplication
• Mutation details: This mutation is believed to have originated in a (C3H/HeH x 101/H)F1 female mouse that received 1 Gy X-rays shortly before ovulation and was then mated to a tester (PT) male. The original "mutant" male exhibited a tail kink, but was normal in size. His offspring had normal tails but included one animal with much reduced body weight compared to its sibs; this mouse transmitted the size phenotype. Analysis of G-banded chromosomes from a mouse with this phenotype revealed that Chr 1 is ~30% longer than its normal homolog and appears to contain a duplication either of bands D to E4 or of bands E1 to F. Staining with Chr 1 "paint" confirms that the extra material is of Chr 1 origin. (J:192800)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dp(1)21H Mutation: 0 strains or lines available

References

• Original: J:192800 Tease C, et al., A further duplication involving chromosome 1, Dp(1)21H. Mouse Genome. 1996;94(3):680-681
• All: 1 reference(s)