Eif4g1^tm1.1Mjff
Targeted Allele Detail

Summary

• Symbol: Eif4g1^tm1.1Mjff
• Name: eukaryotic translation initiation factor 4, gamma 1; targeted mutation 1.1, The Michael J Fox Foundation
• MGI ID: MGI:5466854
• Synonyms: Eif4g1^R1207H
• Gene: Eif4g1 Location: Chr16:20491457-20511633 bp, + strand Genetic Position: Chr16, 12.49 cM
• Alliance: Eif4g1^tm1.1Mjff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting vector was designed (by site-directed mutagenesis) to insert the arginine to histidine amino acid substitution at position 1207 (R1207H) (human 1205) into exon 24 and place a loxP site upstream of exon 24, followed by an FRT-flanked neomycin cassette and a loxP site downstream of exon 28. Flp-mediated recombination removed the neomycin cassette. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Eif4g1 Mutation: 62 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)