Atf5^tm1Mrgr
Targeted Allele Detail

Summary

• Symbol: Atf5^tm1Mrgr
• Name: activating transcription factor 5; targeted mutation 1, Michael R Green
• MGI ID: MGI:5467393
• Synonyms: Atf5^LacZ
• Gene: Atf5 Location: Chr7:44461680-44466082 bp, - strand Genetic Position: Chr7, 28.92 cM
• Alliance: Atf5^tm1Mrgr page

Absence of milk spot in Atf5^tm1Mrgr/Atf5^tm1Mrgr neonates

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191236
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: A lacZ and neo cassette replaced the coding sequence in exon 2 and all of exon 3. qRT-PCR confirmed the absence of transcript expression in the olfactory epithelium. (J:191236)

Generation of the Atf5^tm1Mrgr allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atf5 Mutation: 21 strains or lines available

References

• Original: J:191236 Wang SZ, et al., Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18589-94
• All: 2 reference(s)