Fam3c^{tm2(FAM3C)Lex}
Targeted Allele Detail

Summary

• Symbol: Fam3c^{tm2(FAM3C)Lex}
• Name: FAM3 metabolism regulating signaling molecule C; targeted mutation 2, Lexicon Genetics
• MGI ID: MGI:5467559
• Gene: Fam3c Location: Chr6:22306519-22356080 bp, - strand Genetic Position: Chr6, 9.24 cM
• Alliance: Fam3c^{tm2(FAM3C)Lex} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188156
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 3 was replaced with an IRES, the human open reading frame, mouse MT2 exon 2 and 3 with polyadenylation sequence and a floxed neo cassette. This is a loss of function allele. (J:188156)

Generation of the Fam3c^tm2(FAM3C)Lex allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fam3c Mutation: 31 strains or lines available

References

• Original: J:188156 Zheng HF, et al., WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genet. 2012 Jul;8(7):e1002745
• All: 1 reference(s)