Pou4f3^{tm1.1(HBEGF)Jsto}
Targeted Allele Detail

Summary

• Symbol: Pou4f3^{tm1.1(HBEGF)Jsto}
• Name: POU domain, class 4, transcription factor 3; targeted mutation 1.1, Jennifer S Stone
• MGI ID: MGI:5467563
• Synonyms: Pou4f3^DTR
• Gene: Pou4f3 Location: Chr18:42527662-42529158 bp, + strand Genetic Position: Chr18, 22.58 cM, cytoband B3-E1
• Alliance: Pou4f3^{tm1.1(HBEGF)Jsto} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191218
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x C3H

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Pou4f3^{tm1.1(HBEGF)Jsto} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: The full coding region of human diphtheria toxin receptor (HBEGF) and a floxed neo cassette were inserted upstream of the translation initiation site. Cre-mediated recombination removed the neo cassette. (J:191218)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pou4f3 Mutation: 25 strains or lines available

References

• Original: J:191218 Golub JS, et al., Hair cell replacement in adult mouse utricles after targeted ablation of hair cells with diphtheria toxin. J Neurosci. 2012 Oct 24;32(43):15093-105
• All: 20 reference(s)