H2-Oa/Brd2^{Tg(otx2-lacZ)F5pImat}
Transgenic Allele Detail

Summary

• Symbol: H2-Oa/Brd2^{Tg(otx2-lacZ)F5pImat}
• Name: histocompatibility 2, O region alpha locus; transgene insertion F5p, Isao Matsuo
• MGI ID: MGI:5467632
• Synonyms: Brd2^F5placZ, Brd2^tg
• Gene: H2-Oa Location: Chr17:34311314-34314208 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: H2-Oa/Brd2^{Tg(otx2-lacZ)F5pImat} page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Null/knockout, Reporter)
• Mutations: Insertion, Intergenic deletion
• Mutation details: The F5placZ construct contains -29 to -18 kb 5'-upstream region of the Fugu otx2 gene fused with the Fugu otx2 promoter, the lacZ gene and the SV40 polyA signal. In line F5p, insertion of the transgene results in a 39.9 kb deletion of H2-Oa and Brd2 (deletion from the third to last exon). (J:188139, J:193089)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H2-Oa Mutation: 11 strains or lines available

References

• Original: J:193089 Kimura-Yoshida C, et al., Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for vertebrate head specification. Development. 2004 Jan;131(1):57-71
• All: 2 reference(s)