Mirc14^tm1.1Czc
Targeted Allele Detail

Summary

• Symbol: Mirc14^tm1.1Czc
• Name: microRNA cluster 14, including Mir181a-1 through Mir181b-1; targeted mutation 1.1, Chang-Zheng Chen
• MGI ID: MGI:5467776
• Synonyms: mir181a1b1^f
• Gene: Mirc14 Location: Chr1:137894193-137894456 bp Genetic Position: Chr1, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188125
• Parent Cell Line: CGR8 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: LoxP sites were inserted at least 125 bp upstream and downstream of the cluster. Flp-mediated recombination removed an FRT-flanked neo cassette. (J:188125)

Generation of the Mirc14^tm1.1Czc and Mirc14^tm1.2Czc alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mirc14 Mutation: 1 strain or line available

References

• Original: J:188125 Fragoso R, et al., Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1. PLoS Genet. 2012 Aug;8(8):e1002855
• All: 2 reference(s)