Ttll5^tm1.1N
Targeted Allele Detail

Summary

• Symbol: Ttll5^tm1.1N
• Name: tubulin tyrosine ligase-like family, member 5; targeted mutation 1.1, National Institutes of Health
• MGI ID: MGI:5467943
• Synonyms: Stamp^tm
• Gene: Ttll5 Location: Chr12:85871417-86100534 bp, + strand Genetic Position: Chr12, 39.81 cM, cytoband D3
• Alliance: Ttll5^tm1.1N page

Disrupted axoneme in Ttll5^tm1.1N/Ttll5^tm1.1N sperm tails

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94077
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

Allele Type: Targeted (Hypomorph) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 23. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 24. Cre-mediated recombination removed exon 23, exon 24 and the neomycin resistance cassette. Because of the possibility of truncated protein expression, this allele could be hypomorphic. (J:94077)

Generation of the Ttll5^tm1N and Ttll5^tm1.1N alleles

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ttll5 Mutation: 66 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 5 reference(s)