Rps6ka5^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Rps6ka5^tm1.1Arte
• Name: ribosomal protein S6 kinase, polypeptide 5; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5467986
• Synonyms: MSK1^KD
• Gene: Rps6ka5 Location: Chr12:100514692-100691693 bp, - strand Genetic Position: Chr12, 50.81 cM
• Alliance: Rps6ka5^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188104
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 5 was replaced with one in which nucleotide substitutions result in the amino acid substitution of alanine for aspartic acid at position 194 (D194A). Flp-mediated recombination removed the FRT-flanked neo cassette inserted downstream of the modified exon 5. The predicted protein product is expected to be a kinase dead version. (J:188104)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rps6ka5 Mutation: 64 strains or lines available

References

• Original: J:188104 Correa SA, et al., MSK1 Regulates Homeostatic and Experience-Dependent Synaptic Plasticity. J Neurosci. 2012 Sep 19;32(38):13039-13051
• All: 6 reference(s)