Rbm4^tm1Wtarn
Targeted Allele Detail

Summary

• Symbol: Rbm4^tm1Wtarn
• Name: RNA binding motif protein 4; targeted mutation 1, Woan-Yuh Tarn
• MGI ID: MGI:5467987
• Synonyms: Rbm4a^-
• Gene: Rbm4 Location: Chr19:4834321-4843929 bp, - strand Genetic Position: Chr19, 4.11 cM, cytoband A
• Alliance: Rbm4^tm1Wtarn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192831
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing most of exon 2 was replaced with a promoterless EGFP cassette and a floxed neo cassette via homologous recombination. This exon is also part of the overlapping predicted gene Gm21992. RT-PCR confirmed the absence of mRNA expression in homozygous MEFs and detected an increase in expression of Rbm4b . (J:192831)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbm4 Mutation: 26 strains or lines available

References

• Original: J:192831 Lin JC, et al., RBM4 promotes pancreas cell differentiation and insulin expression. Mol Cell Biol. 2013 Jan;33(2):319-27
• All: 11 reference(s)