Rbm4b^tm1Wtarn
Targeted Allele Detail

Summary

• Symbol: Rbm4b^tm1Wtarn
• Name: RNA binding motif protein 4B; targeted mutation 1, Woan-Yuh Tarn
• MGI ID: MGI:5467988
• Gene: Rbm4b Location: Chr19:4806480-4816199 bp, + strand Genetic Position: Chr19, 4.11 cM
• Alliance: Rbm4b^tm1Wtarn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192831
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing most of exon 2 was replaced with a promoterless DsRed-mammalian sterile 20 cassette and a floxed neo cassette via homologous recombination. RT-PCR confirmed the absence of mRNA expression in homozygous MEFs and detected an increase in expression of Rbm4 . (J:192831)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbm4b Mutation: 16 strains or lines available

References

• Original: J:192831 Lin JC, et al., RBM4 promotes pancreas cell differentiation and insulin expression. Mol Cell Biol. 2013 Jan;33(2):319-27
• All: 3 reference(s)