Fance^{Tg(Tyr)2364E-2a2Ove}
Transgenic Allele Detail

Summary

• Symbol: Fance^{Tg(Tyr)2364E-2a2Ove}
• Name: Fanconi anemia, complementation group E; transgene insertion 2364E-2a2, Paul Overbeek
• MGI ID: MGI:5467996
• Synonyms: Fance^{Tg(Tyr)OVE2364E-2a2Chfu}
• Gene: Fance Location: Chr17:28532504-28545548 bp, + strand Genetic Position: Chr17, 14.65 cM
• Alliance: Fance^{Tg(Tyr)2364E-2a2Ove} page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The Tyrosinase minigene is composed of the mouse Tyr enhancer region (623 bp), promoter region (657 bp), and 1566 bp cDNA sequence (including the stop codon). The Tyro minigene is followed by an internal ribosome entry site (IRES) ending with ATGs in all three reading frames (3xATG), an artificial splice donor sequence, and a loxP site. Using inverse PCR analysis, the lentiviral integration site was identified in intron 8 of the Fanconi anemia E gene (Fance) on chromosome 17. The 3'-LTR is linked to the (+) strand of DNA at position 28,458,210 bp [NCB137/mm9; 3'-28,458,210(+)]. (J:251511)

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fance^{Tg(Tyr)2364E-2a2Ove}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fance Mutation: 21 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 6 reference(s)