Jak3^M1Pgrs
Chemically induced Allele Detail

Summary

• Symbol: Jak3^M1Pgrs
• Name: Janus kinase 3; mutation 1, Philippe Gros
• MGI ID: MGI:5468008
• Synonyms: Jak3^W81R, P48
• Gene: Jak3 Location: Chr8:72129027-72143221 bp, + strand Genetic Position: Chr8, 34.43 cM
• Alliance: Jak3^M1Pgrs page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A transversion in exon 2 results in the amino acid susbtitution of arginine for tryptophan at position 81 (W81R). (J:185217)
• Inheritance: Codominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jak3 Mutation: 84 strains or lines available

References

• Original: J:185217 Bongfen SE, et al., An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria. PLoS One. 2012;7(2):e31012
• All: 2 reference(s)