Cd247tm2Lov
Targeted Allele Detail
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Symbol: |
Cd247tm2Lov |
Name: |
CD247 antigen; targeted mutation 2, Paul E Love |
MGI ID: |
MGI:5468024 |
Synonyms: |
TCRzeta6Y |
Gene: |
Cd247 Location: Chr1:165616250-165704846 bp, + strand Genetic Position: Chr1, 73.14 cM, cytoband G-H
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Alliance: |
Cd247tm2Lov page
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Germline Transmission: |
Earliest citation of germline transmission:
J:192915
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Not Applicable) |
Mutation: |
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Insertion
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Mutation details: Exons 3 through 8 were replaced with the corresponding wild-type sequence with a C-terminal FLAG tag (6Y-FLAG), an FRT-flanked neo cassette, a loxP site and the corresponding sequence in which the six immunoreceptor tyrosine-based activation motif (ITAM) tyorsines mutated to encode phenylalanine followed by a C-terminal Myc tag (6F-Myc).
(J:192915)
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Generation of the Cd247tm2Lov and Cd247tm2.1Lov alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cd247 Mutation: |
11 strains or lines available
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Original: |
J:192915 Hwang S, et al., Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease. J Exp Med. 2012 Sep 24;209(10):1781-95 |
All: |
3 reference(s) |
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