Agtr1a^tm1.1Uky
Targeted Allele Detail

Summary

• Symbol: Agtr1a^tm1.1Uky
• Name: angiotensin II receptor, type 1a; targeted mutation 1.1, Katherine Adams
• MGI ID: MGI:5468252
• Synonyms: Agt1ar^lox, AT1aR^fl
• Gene: Agtr1a Location: Chr13:30520424-30566850 bp, + strand Genetic Position: Chr13, 13.19 cM
• Alliance: Agtr1a^tm1.1Uky page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192945
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 3 followed by a neomycin resistance (neo) cassette flanked by frt sites and loxP sites downstream of exon 3 of the angiotensin II receptor, type 1a (Agtr1a) gene. Flp-mediated recombination removed the neo cassette and left exon 3 floxed. (J:192945)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agtr1a Mutation: 40 strains or lines available

References

• Original: J:192945 Putnam K, et al., Deficiency of angiotensin type 1a receptors in adipocytes reduces differentiation and promotes hypertrophy of adipocytes in lean mice. Endocrinology. 2012 Oct;153(10):4677-86
• All: 3 reference(s)