Gfi1^{tm6.1(GFI1)Tmo}
Targeted Allele Detail

Summary

• Symbol: Gfi1^{tm6.1(GFI1)Tmo}
• Name: growth factor independent 1 transcription repressor; targeted mutation 6.1, Tarik Moroy
• MGI ID: MGI:5468264
• Synonyms: Gfi1^36S
• Gene: Gfi1 Location: Chr5:107864521-107873671 bp, - strand Genetic Position: Chr5, 52.23 cM
• Alliance: Gfi1^{tm6.1(GFI1)Tmo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192927
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of the coding sequence was replaced with the corresponding human sequence with the most common variant of serine at position 36 (36S). Cre-mediated recombination removed a floxed neo cassette inserted upstream of the last coding exon. (J:192927)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfi1 Mutation: 31 strains or lines available

References

• Original: J:192927 Khandanpour C, et al., The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice. Blood. 2012 Nov 8;120(19):4006-17
• All: 6 reference(s)