Dlc1^tm1.1Lowy
Targeted Allele Detail

Summary

• Symbol: Dlc1^tm1.1Lowy
• Name: deleted in liver cancer 1; targeted mutation 1.1, Douglas R Lowy
• MGI ID: MGI:5468314
• Synonyms: Dlc1^fl
• Gene: Dlc1 Location: Chr8:37034905-37420297 bp, - strand Genetic Position: Chr8, 23.05 cM, cytoband A4-B2
• Alliance: Dlc1^tm1.1Lowy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192878
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Exon 4 was floxed. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:192878)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlc1 Mutation: 227 strains or lines available

References

• Original: J:192878 Qian X, et al., Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16Ink4a, leading to neoplastic transformation and poor prognosis in human cancer. Cancer Res. 2012 Nov 15;72(22):5900-11
• All: 1 reference(s)